CBD is short for Cannabidiol, one of the major phytocannabinoids made by the plant genus Cannabis sativa. It’s a 21-carbon molecule with a central 6-carbon ring and side chains, and was the first cannabinoid isolated and deciphered in 1963 by Israeli researcher, Dr. Raphael Mechoulam.
CBD – Psychoactive
Unlike THC, which is responsible for causing the “high” associated with cannabis, CBD is non-intoxicating. This doesn’t make it non-psychoactive. Described in literature as having anti-stress, anti-anxiety, calming, relaxing, antipsychotic, and anti-seizure properties.
What are CBD’s benefits?
Many illnesses can be traced back to dysfunction in the endocannabinoid system (ECS), which is essentially designed to keep our bodies in homeostasis or balance.
Think of the ECS as the control board of health. When the control board malfunctions, the result manifests as symptoms of illness or disease. Research has shed some light on this, classifying conditions like migraine headaches, fibromyalgia, IBS, and PTSD as true endocannabinoid deficiency syndromes. Uncontrolled inflammation, chronic pain, chronic stress, seizure disorders, and cancer are also linked to ECS dysfunction.

CBD blocks the enzyme FAAH that breaks down the endogenous cannabinoids anandamide and 2-AG. This inhibition results in higher levels of endocannabinoids available to CB1 and CB2, which is important because those endogenous cannabinoids play a big role in things like feelings of well-being, sleep, inflammation and overall endocannabinoid system balance and tone.
Lastly, CBD works on over 65 other cellular receptors in the body, including pathways involving other neurotransmitters. These non-ECS targets include serotonergic, glutamatergic, opioid, and vallinoid pathways, which are highly involved in the regulation of mood, motivation, anxiety and pain.
CBD even affects the signaling molecules important in our immune system, like cytokines. Many clinician researchers believe its CBD’s indiscriminate behavior that results in such broad-ranging effects.
Benefits
CBD may benefit a person’s health in various ways.
According to a 2018 study, reasons for taking CBD oil include:
- chronic pain
- arthritis or joint pain
- anxiety and depression
- sleep disorder
- migraine
- cluster and other headaches
- post-traumatic stress disorder (PTSD)
- nausea
- cancer
- allergies or asthma
- epilepsy and other seizure disorders
- multiple sclerosis (MS)
- lung conditions
- Parkinson’s disease
- Alzheimer’s disease
There is some evidence to support some of these uses.
SO, HOW DOES CBD FIT IN?
Endocannabinoid deficiency disorders, like those listed above, are disorders involving low endocannabinoid levels. In western medicine, we treat disorders of deficiency with supplementation – think: vitamin D supplements to treat vitamin D deficiency. So when it comes to supplementing endocannabinoid deficiencies, clinician researchers get a little creative.
Is CBD Safe?
CBD is a phytocannabinoid. It’s a single chemical and a drug. When consumers use CBD, they aren’t using just CBD. They are typically using it as a component of full- or broad-spectrum personal care products. A full- or broad-spectrum product includes other naturally occurring phytochemicals (like terpenes) extracted along with CBD, meaning that product does not contain CBD alone.

In this form, CBD is considered very safe. In clinical jargon, we use the term “risk profile” to reference the benefits of any medication in comparison to the risks (i.e., adverse effects or toxicity). Most of the adverse effects of using cannabis, such as intoxication, short term memory loss, anxiety, and rapid heart beat can be attributed to THC and not to CBD.
CBD and epileptic seizures
For children with epilepsy, many treatment options drag along a host of side effects that impact one’s quality of life. So when CBD began to show promise as an effective treatment for seizures with little in the way adverse effects, researchers started paying attention.
In 2018, the FDA approved a CBD-based medicine called Epidiolex for treating two forms of epilepsy—Dravet syndrome and Lennox-Gastaut syndrome.
Although anecdotal evidence and early studies show promising results, researchers haven’t yet reached a scientific explanation for why CBD might help reduce seizures.
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